How does Lisinopril work in the body?
Lisinopril is a long-acting medicine intended to treat hypertension (high blood pressure). In addition, the drug is suitable for preventing the development of high blood pressure and prevents complications associated with it. The advantage of Lisinopril is that it can be prescribed to overweight patients because its metabolism does not occur in the body’s fat tissue. Lisinopril can be recommended by a cardiologist, and you can buy it at a pharmacy or online store. The drug is dispensed according to a doctor’s prescription.
The active ingredient of Lisinopril is lisinopril dihydrate, which reduces the release of aldosterone, a hormone responsible for water-salt metabolism. Increases the amount of bradykinin, which affects vasodilation, thereby reducing blood pressure. In addition, Lisinopril increases the production of prostaglandins, which reduces the severity of inflammatory processes and eliminates pain. Lisinopril increases blood supply to the myocardium and inhibits its hypertrophy, that is, it significantly reduces the likelihood of developing myocardial infarction.
The drug is part of maintenance therapy for people with chronic heart failure, improving the quality of life of patients and increasing its duration. This result can only be achieved with long-term therapy.
How quickly does Lisinopril take effect.
Lisinopril is available in tablet form in various dosages (5 mg, 10 mg and 20 mg), and after taking the drug, it is active in the body within an hour. The effectiveness of the medicine does not depend on food intake. The maximum effect is achieved after 6-7 hours and lasts throughout the day. For hypertension, the patient may feel better in the first days of taking Lisinopril. A persistent therapeutic effect is observed after approximately 2-4 months of regular use. If the effect of treatment is insufficient or absent, the doctor will prescribe a scheme for gradually increasing the dosage of Lisinopril every few days (up to a maximum of 40 mg of the drug per day).
For what diseases is Lisinopril prescribed?
Lisinopril is most often used as part of combination drug therapy to treat the following diseases:
- Persistent increase in blood pressure (primary and secondary hypertension).
- Chronic congestive heart failure.
- Acute myocardial infarction in the early stages of therapy.
- Diabetic kidney disorder.
Are there any contraindications to taking Lisinopril?
- high sensitivity to the drug, as well as to other drugs with a similar mechanism of action;
- tendency to Quincke’s edema, or edema of unknown nature;
- under 18 years of age, since there is no reliable data on the safety of the drug for children.
Can pregnant women and nursing mothers with hypertension take Lisinopril?
Lisinopril is not recommended during pregnancy because the active substance crosses the placenta. Taking Lisinopril in the later stages is most dangerous, since it has a negative effect on the fetus, including death. There is no data on the effect of Lisinopril on breast milk, so taking it during lactation is not recommended.
How to take Lisinopril correctly?
Lisinopril is taken orally, once in the morning. The effectiveness of the drug is higher if taken at the same time.
Primary hypertension:
- 10 mg/day for the first time;
- for a maintenance effect, the dose is increased to 20 mg (or higher, but not more than 40 mg per day).
If the maximum dose of Lisinopril does not help sufficiently, another antihypertensive drug is additionally prescribed.
If the patient was taking diuretics before starting treatment, they should be discontinued and therapy should be started after 3 days. If discontinuation of diuretics is not possible, the dosage of Lisinopril is reduced to 5 mg per day.
Hypertension resulting from decreased blood flow in the renal arteries:
The recommended dose is 2.5-5 mg per day. In this case, you need to measure blood pressure daily and monitor the function of the genitourinary system, as well as regularly take tests to determine the level of potassium in the blood. The maintenance dose is set depending on the blood pressure. The maximum possible daily dose is up to 20 mg.
Heart attack:
Lisinopril in such a situation is prescribed along with other drugs under medical supervision. The initial dosage is 2.5-5 mg per day. Then the dosage is gradually increased according to the scheme selected by the cardiologist. If a patient with an acute heart attack experiences a rapid and persistent drop in pressure, the drug should be discontinued.
Renal dysfunction in diabetes:
The recommended initial dose is 10 mg Lisinopril per day. It can be increased to a maximum of 20 mg per day, with mandatory checking of lower pressure in a sitting position.
What side effects can be observed during treatment with Lisinopril?
The most common side effects:
- dizziness;
- headache;
- severe fatigue, drowsiness and weakness;
- upset stomach, loss of appetite, nausea and abdominal pain;
- cough without sputum;
- rapid decrease in blood pressure:
- chest pain;
- mood swings;
- confusion;
- violation of the quantitative composition of blood;
- low hemoglobin level;
- shortness of breath;
- weight loss;
- bronchospasm;
- dryness of the oral mucosa;
- changes in taste sensations;
- pancreatitis;
- increased liver enzymes, jaundice and hepatitis.
Sometimes allergic reactions of varying degrees of intensity are observed when taking Lisinopril.
What to do if an overdose occurs?
In case of an overdose of the drug, a strong decrease in blood pressure, dry mouth, drowsiness, problems with urination, irritability and causeless anxiety are observed. Treatment is aimed at eliminating symptoms. In some cases, hemodialysis is prescribed.
Where can you buy Lisinopril without a doctor’s prescription?
Lisinopril is a prescription drug, but can be ordered without a prescription at our online pharmacy. But it is important to understand that taking Lisinopril without medical supervision is dangerous, so in no case should you self-medicate.
Is it possible to buy a high-quality analogue of Lisinopril at a low cost?
There are many counterfeits on the pharmaceutical market that may simply be ineffective or even dangerous. But there are high-quality analogues that have a similar active ingredient in their composition and provide a good therapeutic effect. This analogue is the generic Lisinopril, which can be ordered in our online pharmacy. It helps fight hypertension in exactly the same way as the original Lisinopril, but at the same time has a low cost. This way you can buy a quality drug and save a lot.
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